February Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
NOTE: This is a special joint meeting with the New Jersey Discussion Group. The meeting will be in Princeton NJ on a Tuesday. If you are going to the dinner you must make reservations.
- Topic: "TOFs, Traps and T-Cells: New Instrumentation for Biological Research
- Speaker: Dr. Robert J. Cotter, Johns Hopkins University.
- Date: Tuesday, February 8th, 2000. 7:00 PM
- Time: Social Hour: 5:00 PM.
Dinner: 6:00 PM
Talk: 7:00 PM.
- Buffet Dinner: $30. Dinner reservation deadline: Thursday, February 3rd. Preregistration is required. e-mail to Scott Van Bramer at email@example.com . Include name and corporate affiliation. If you do not have e-mail access, leave a message at 610/499-4516. Please be responsible and cancel your reservation if you do not plan to attend.
- Place: Marriott Forrestal Village (Princeton)
- Abstract: The MAMS laboratory developed the curved-field reflectron, which makes it possible to record post-source decay (PSD) mass spectra from a time-of-flight instrument without scanning or stepping the reflectron. A newer reflectron system, the endcap reflectron, provides high order kinetic energy focusing and the potential for miniaturizing the mass spectrometer for bioagent detection. These instruments are being used to identify viral antigens bound to the major histocompatability (MHC) molecule and presented to killer T-cells. While classical MHC molecules present endogenous peptides to the T-cell receptor (TCR), non-classical Qa-1 molecules may present bacterial antigens that mimic self-antigens, while CD1 presents a glycolipid. In addition, a method for rapidly assessing allelic variations in the DNA encoding MHC can be used to match donor and recipient for tissue transplantation. Tandem mass spectrometry provides considerable advantage in determining the structures of tumor or viral antigens, which are presented along with self-antigens. In addition to PSD, we have continued our development of MALDI on an ion trap mass spectrometer for elucidating these structures.
- Bio:Dr. Robert J. Cotter. Professor of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine. President, American Society for Mass Spectrometry
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