November 2000 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group

• Topic: "Evolutionary vs. Revolutionary Changes: Now vs. Lab-0n-Chip Chemistries Coupled with Mass Spectrometry"

• Speaker: Jack Henion, Advanced BioAnalytical Services, Inc. and Cornell University

• Date: Wednesday, November 29, 2000. 7:00 PM

• Time: Social Hour: 7:00 PM.
  Talk: 7:30 PM.

• Place: Merck, West Point, 37 Auditorium

• Abstract: There continues to be considerable interest in chip-based separation science (capillary electrophoresis and HPLC) and modern analysis strategies. We believe that mass spectrometry is an important component of any modern successful strategy that is faced with high sensitivity and specificity requirements. Significant opportunities appear to be available if successful LC/MS and CE/MS could be possible from chip-based devices.

  Currently both of my research laboratories is aggressively exploring new technologies which could make these exciting analytical techniques routinely available in the foreseeable future. We are interested in application areas which include proteomics, genomics, combinatorial chemistry characterization, and ADME studies which are so important to the pharmaceutical industry. These studies include simple infusion or sample pick-up methods to directly analyze simple mixtures as well as on-line separations employing either CE or HPLC to provide further cleanup of complex samples prior to mass spectrometric detection.

  This lecture will review our progress towards coupling chip-based organic chemistry which includes small molecule drugs in addition to proteins and tryptic digests. Two different strategies will be described and convincing results which demonstrate these techniques may be available sooner than you might think will be shown.

• Bio: Jack Henion is Professor of Toxicology at Cornell University where he has been a member of the College of Veterinary Medicine since 1976. During his tenure at Cornell Professor Henion has conducted research and applications in many areas of liquid chromatography/mass spectrometry (LC/MS) and related areas using conventional ionization sources and atmospheric pressure ionization (API) sources. In addition to research in LC/MS techniques Professor Henion has also been active in related areas which couple other separation sciences techniques to mass spectrometry including capillary electrophoresis (CE/MS), supercritical fluid chromatography (SFC/MS), ion chromatography (IC/MS), and immunoaffinity chromatography (IAC/MS). He has also played a leadership role in combining coupled-column HPLC techniques with atmospheric pressure ionization-tandem mass spectrometry (LC/LC/MS/MS). More recently he has explored new strategies of sample preparation targeted for LC/MS applications with the goal of high throughput LC/MS/MS capability. More recently his research interests include ion spray mass spectrometric detection of biospecific noncovalent interactions, use of affinity techniques both on-line and off-line with LC/MS techniques, implementation of LC/MS and CE/MS on benchtop and research-grade ion trap mass spectrometers, studies using time-of-flight (TOF) MS for LC/MS analysis of biological samples, and microfabrication techniques to reduce CE/MS techniques to chip-based CE/MS applications for the pharmaceutical industry. Recently Prof. Henion joined the Editorial Board of the Journal of the American Society for Mass Spectrometry. Dr. Henion has received two Doctor Honoris Causa (Honorary Doctorate) degrees in recognition of his international reputation in modern analytical techniques. One is from the University of Ghent, Belgium for his work in trace residue analysis in biological samples, and the other was awarded in May, 2000 from the University of Uppsala, Sweden in recognition of his research in modern LC/MS/MS bioanalytical techniques.

  Professor Henion established a new contract research laboratory in April, 1993 called Advanced BioSciences, Inc. (ABS) located in Ithaca, NY. ABS's mission is to become the premier contract LC/MS/MS facility for the Pharmaceutical and Agrochemical industries of the future. Dr. Henion is President, CEO, and Chairman of the Board of ABS. The Company currently provides high-quality LC/MS/MS analytical services for selected premier pharmaceutical and agrochemical companies in the US and Europe. It currently employs 71 individuals, and has 15 tandem API mass spectrometers as well as two TOF-MS systems. ABS's core mission is to provide leadership in high-quality contract research analytical services using modern analytical technologies in support of new products to benefit the health of mankind. During the past two years ABS has initiated a major new R&D effort to develop microfabricated analytical devices to provide improved LC/MS techniques and strategies for the future.

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