Social Hour | 5:30-6:30 pm |
Dinner | 6:30-7:30 pm |
Lecture | 7:30-9:00 pm |
I will consider the role that modern proteomic approaches are beginning to play in the formidable undertaking of describing and understanding complex biological processes mediated by protein molecules. In particular, I will discuss the use of new mass spectrometric methods to rapidly identify proteins, determine posttranslational modifications, quantitate changes in the levels of protein expression and site specific protein modifications, elucidate the myriad interactions of proteins, and assist in the determination of their three-dimensional structure and function.
He carried out postdoctoral research at the University of Manitoba, where together with Professor Kenneth G. Standing, he constructed the first pulsed ion bombardment time-of-flight mass spectrometer. Subsequently Dr. Chait moved to the United States where he joined the laboratory of Professor Frank H. Field, and constructed a number of mass spectrometers designed to measure biological macromolecules. He is currently Camille and Henry Dreyfus Professor at Rockefeller and Head of the Laboratory for Mass Spectrometry and Gaseous Ion Chemistry. He also directs the NIH-funded National Resource for the Mass Spectrometric Analysis of Biological Macromolecules.
His current research focuses on investigations of new techniques for volatilizing and ionizing proteins, designing and constructing novel mass spectrometers, and developing mass spectroscopic-based methodology to assist in the solution of challenging biological problems. He and his colleagues are applying these tools to the solution of biological problems that involve, for example, the rapid identification of proteins, the elucidation of posttranslational modifications and the definition of sites of functional interaction between biomolecules.
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