March 2001 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
NOTE: This is a special joint meeting with the New Jersey Discussion Group. The meeting will be in Princeton NJ on a Tuesday. If you are going to the dinner you must make reservations.
- Topic: "Proteomic tools for Dissecting Cellular Function"
- Speaker: Brian T. Chait, Rockefeller University, 1230 York Ave., New York, NY
- Date: Tuesday, March 13, 2001. 6:30 PM
|Social Hour ||5:30-6:30 pm |
|Dinner ||6:30-7:30 pm|
|Lecture||7:30-9:00 pm |
Cost: $15 ($10 for students)
Dinner reservation deadline: Friday, March 9th, Preregistration is required. We prefer that you make reservations on the web (www.njacs.org/ms.html) or e-mail to Swapan Chowdhury (firstname.lastname@example.org). Include name and corporate affiliation. If you do not have e-mail access, call Cornelis Hop (732-594-4274), Mark Hayward (908-277-7357), Richard Klein (201-796-6127) or Swapan Chowdhury (908-740-7198). Please be responsible and cancel your reservation if you do not plan to attend. Please be responsible and cancel your reservation if you do not plan to attend.
- Place: Princeton Marriott (Princeton)
- Abstract: A detailed understanding of any given biological process in a living cell requires knowledge of all of the molecular players involved in the process, as well as their spatial distribution, concentration, interactions and control. The enormity of this task can be appreciated by considering the protein complement of a typical human cell, which is estimated to contain tens of thousands of unique proteins - many of which undergo modifications and alterations in their interactions during the course of the biological process. To make matters even more challenging, the proteins may be present at levels that range between just a few copies to millions of copies per cell, with the level of a given protein often changing as a function of time.
I will consider the role that modern proteomic approaches are beginning to play in the formidable undertaking of describing and understanding complex biological processes mediated by protein molecules. In particular, I will discuss the use of new mass spectrometric methods to rapidly identify proteins, determine posttranslational modifications, quantitate changes in the levels of protein expression and site specific protein modifications, elucidate the myriad interactions of proteins, and assist in the determination of their three-dimensional structure and function.
- Bio: Brian T. Chait was born in Cape Town, South Africa on July 6, 1949. He received his B. Sc. (1969) and B. Sc. (Hons) (1970) from the University of Cape Town and D.Phil. (1976) in experimental nuclear physics from Oxford University.
He carried out postdoctoral research at the University of Manitoba, where together with Professor Kenneth G. Standing, he constructed the first pulsed ion bombardment time-of-flight mass spectrometer. Subsequently Dr. Chait moved to the United States where he joined the laboratory of Professor Frank H. Field, and constructed a number of mass spectrometers designed to measure biological macromolecules. He is currently Camille and Henry Dreyfus Professor at Rockefeller and Head of the Laboratory for Mass Spectrometry and Gaseous Ion Chemistry. He also directs the NIH-funded National Resource for the Mass Spectrometric Analysis of Biological Macromolecules.
His current research focuses on investigations of new techniques for volatilizing and ionizing proteins, designing and constructing novel mass spectrometers, and developing mass spectroscopic-based methodology to assist in the solution of challenging biological problems. He and his colleagues are applying these tools to the solution of biological problems that involve, for example, the rapid identification of proteins, the elucidation of posttranslational modifications and the definition of sites of functional interaction between biomolecules.
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