In the late part of 1995, Dr. Kassel joined CombiChem, Inc. as Director of Analytical Technologies. His research team developed state-of-the-art analytical tools to aid the drug discovery process. His seminal contributions to the field of combinatorial chemistry have included the design, development and implementation of automated preparative HPLC/MS for the purification of compound libraries. In addition, his team developed an array of parallel HPLC/MS systems for ultra-high throughput analysis, purification and in vitro ADME profiling of combinatorial libraries. Dr. Kassel has co-authored more than 40 papers, principally in the area of LC/MS, serves as a reviewer for many journals, and is editorial board member of Combinatorial Chemistry & High Throughput Screening. He has been an invited speaker at numerous conferences both nationally and internationally, has chaired several mass spectrometry conferences and organized several short courses and workshops, including the well-received ASMS short courses on "Mass Spectrometry of Peptides and Proteins" and "Mass Spectrometry and Combinatorial Chemistry."
In November of 1999, CombiChem, Inc. was acquired by Dupont Pharmaceuticals, maintaining west-coast operations in sunny San Diego. Dr. Kassel and his team continue to develop state-of-the-art technology for drug discovery. Recent efforts have focussed on increasing sample throughput for analysis, purification and in vitro ADME profiling of compound libraries. A major emphasis has been placed on developing and implementing high throughput ADME assays and parallel analysis tools to accelerate drug discovery. In addition, exciting developments in supercritical fluid chromatography-MS as a complement to HPLC/MS have been made for the high throughput analysis and purification of compound libraries.
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