October 2001 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
This Month's speaker is being sponsored by Bruker
- Topic: "Achieving High Mass Resolution and Accurate Mass Measurement in FTICR
- Speaker: Jon Amster University of Georgia
- Date: Monday, October 8, 2001. 6:30 PM
- Time: Social Hour: 6:30 PM. (Pizza and Beer)
Talk: 7:30 PM.
- Place: Widener University, Webb Room.
FTICR mass spectrometry is well known for its high mass resolution and
mass accuracy. These features have made this mass spectrometry method of
great current interest for application to a wide variety of chemical and
biologically related problems. Unlike beam instruments, trapping mass
spectrometers such as the FTICR instrument are sensitive to the density
of ions that are stored in the analyzer. Ion space-charge affects mass
resolution and mass accuracy, and must be accounted for in order to
achieve high performance. This talk will cover some of the fundamental
issues related to ion space charge in FTICR mass spectrometry, and
discuss the impact of this effect on calibration, accurate mass
measurement, and signal-averaging. Ion axialization and remeasurement
will also be presented, as well as other novel advanced techniques, such
as ion accumulation, that are useful for low level detection. The
utility of FTICR for analyzing complex polymer samples and for
high-throughput proteomic measurements will be presented.
Jon Amster received his B.A. in 1977 from Cornell University. His first
exposure to mass spectrometry came as a research assistant in the
Department of Human Genetics, Yale University Medical School, 1977-1979,
where he used GC-MS to identify intermediates in mammalian amino acid
metabolic pathways. He earned his Ph.D. in 1986 from Cornell University,
under the direction of Fred McLafferty. He was a postdoctoral researcher
in the laboratory of Robert McIver, Jr. at the University of California,
Irvine from 1987-1988. He joined the faculty of the University of
Georgia in 1988, where he holds the position of Professor of Chemistry.
Prof. Amster was the recipient of the ASMS Research Award for starting
faculty in 1989. He has served on the Board of Directors of the American
Society of Mass Spectrometry as Member-at-Large for Education,
1998-2000. His research centers around Fourier transform mass
spectrometry, in particular, the development of new methodologies and
instrumentation for solving complex bioanalytical problems.
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