April 2002 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Mass Spectrometry in Biotechnology and Drug Characterization"
- Speaker: Troy D. Wood, State University of New York at Buffalo
- Date: Monday, April 8, 2002. 6:30 PM
- Time: Social Hour: 6:30 PM. (Pizza and Beer)
Talk: 7:30 PM.
- Place: Widener University, University Center Room C
- Abstract: Electrospray ionization (ESI) mass spectrometry has emerged as a formidable tool in modern biomedical research. This is, in no small part, due to its high utility in ionizing large macromolecules from complex biological sources with ever decreasing sample quantities. In addition, ESI gently transfers non-covalent complexes directly from solution into the gas-phase. In this seminar, examples of how ESI mass spectrometry is being used in
biomedical research will be presented. Examples will include using biological chemistry combined with ESI to probe the active amino acids in the enzyme glucokinase, and probing the non-covalent nature of drug-drug interactions using hydrogen-deuterium exchange. The concluding portion of the seminar will discuss the latest results in the development of miniaturized ESI, or nanospray. By replacing traditional nanospray emitter metal coatings with the conductive polymer polyaniline, stable nanospray for hours can be readily achieved with high stability. This has allowed us to achieve sub-attomole detection limits in mass spectrometry using solutions as dilute as 1 nM. Furthermore, results on the application of nanospray to quantitation of peptides will also be shown.
- Bio: Born February 11, 1967, in Elkhart, Indiana, and raised in St. Joseph Co., Indiana, Prof. Troy Wood attended college at Indiana University in Bloomington, where he majored in chemistry and received a B.S. degree in
chemistry with Honors in 1989. Prof. Wood worked one summer at Miles, Inc. (now Bayer) before getting married and starting graduate school at The Ohio State University. He conducted his Ph.D. work with Professor Alan G. Marshall in the area of Laser Desorption Fourier Transform Mass Spectrometry (FTMS).
In 1993, Troy took a postdoctoral position with Professor Fred W. McLafferty at Cornell University. His research area at Cornell was Electrospray Ionization Fourier Transform Mass Spectrometry (ESI-FTMS) of proteins. In 1995 he started his career as an Assistant Professor in the Department of Chemistry at the University at Buffalo, State University of New York. Prof. Wood is currently an Associate Professor of Chemistry and Adjunct Faculty in the Dept. of Structural Biology at U. Buffalo, and an Adjunct Research Professor at the Roswell Park Cancer Institute.
In 2000, Prof. Wood founded Nanogenesys, Inc., which markets nanospray emitters using polyaniline coatings developed in his research group.
Troy and his wife, Marie, have one son born in 1997 and a daughter born in 1999. He is the past FTMS Interest Group Coordinator for the American Society for Mass Spectrometry, and former Chair of the Western New York Section of the American Chemical Society. He enjoys baseball, playing softball, science fiction, and genealogical research.
Please send any comments, corrections, or suggestions to
This page has been accessed
times since 9/15 /96 .
Last Updated WWednesday, March 13, 2002 9:20:14 AM