May Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
Manufacturer's Night, includes dinner and corporate posters. Please RSVP by April 25.
ACS Philadelphia Section,
- Topic: "Selective Smashing of Peptides by Impact on Self-assembled Monolayers: Kinetics and Dynamics of an Alternative Activation Method in Tandem Mass Spectrometry"
- Speaker: Jean H. Futrell, Pacific Northwest National Laboratory, Richland, WA 99352.
- Date: Monday, May 5, 2003. 6:00 PM
- Time: 6:00 Buffet Dinner hosted by Bruker
7:00 Socializing/Vendors presentations
- RSVP for the Dinner to Scott Van Bramer by Friday, April 25.
- Place: Merck, West Point, 37 Auditorium
There has been growing interest in suface-induced dissociation (SID) of ions since it was introduced about a decade ago by Graham Cooks and coworkers. Although there is a growing body of qualitative and semi-quantitative information on SID, very little quantitative information is available. We have addressed this interesting problem using two unique research instruments created at PNNL. One is a five stage tandem Ion Cyclotron Resonance (ICR) instrument which we have used to study the detailed global mechanisms and kinetics of dissociation of a series of model peptides over a broad range of trapping times. The second is a beam scattering apparatus which determines the angular dependence of partitioning of energy transfer into the surface and the recoiling ion. Our first results support the assertion that we can measure threshold energies for dissociation more accurately than other existing methods-e.g., more accurately than photon impact, collisional or thermal activation. We have also discovered quite unexpected kinetics and dynamics features. Finally, the tuning of energy deposition is accomplished by simply changing the offset potential of the ICR cell. Collectively these characteristics make SID with SAMs attractive for both fundamental and applied studies in mass spectrometry.
- Bio: JEAN H. FUTRELL is Senior Battelle Fellow and Chief Science Officer at Pacific Northwest National Laboratory. He serves the Laboratory as Chair of the Council of Fellows and is a member of the Laboratory Director's Senior Leadership Team.
Jean Futrell received his Ph.D. in physical chemistry at the University of California specializing in nuclear and radiation chemistry, working at the Lawrence Berkeley Laboratory in Glenn Seaborg's division. He has published one reference book and over 300 scientific papers in scientific journals plus numerous reports. His research has included chemical kinetics, reaction dynamics, ion-neutral chemistry and physics, collision phenomena and mass spectrometry. His research groups have created a number of novel instruments for investigating these classes of phenomena, including tandem mass spectrometry. This is a core analytical method, and both his pioneering work in the field and his continuing contributions to understanding the basic processes underlying tandem mass spectrometry are the basis of his international reputation in mass spectrometry. His current research has the creation of new instrumentation as a significant component and his continuing interest in tandem mass spectrometry has shifted from gas phase to ion-surface collisions.
Prior to joining PNNL in February 1999 as the first permanent Director of the William R. Wiley Environmental Molecular Sciences Laboratory Jean pursued an academic career of teaching, research and administration. His immediate prior assignment was as Willis F. Harrington Professor of Chemistry, Biochemistry and Chemical Engineering at the University of Delaware. He is Emeritus Professor of Chemistry at the University of Delaware and Adjunct Professor of Chemistry at the University of Utah, the University of Idaho and Washington State University.
Current major external advisory roles include membership in the Chemical Sciences Roundtable of the National Academy of Sciences, the National Science Foundation (NSF) Director's Advisory Committee on Environmental Research and Education (member of Executive Committee), NSF Mathematics and Physical Sciences Advisory Committee, the University of Washington Vice-Provost for Research's Nanoscience Advisory Board, and the Board of Visitors at Washington State University.
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