September 2003 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Towards Single Molecule Mass Spectrometry"
- Speaker: Lloyd M. Smith, Department of Chemistry, University of Wisconsin
- Date: Monday, September 8, 2003. 6:30 PM
- Time: Social Hour: 6:30 PM. (Pizza and Beer)
Talk: 7:30 PM.
- Place: Widener University, Webb Room.
- Abstract: The development in the late '80s of the sister techniques of matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) was responsible for a renaissance in mass spectrometry, opening a window to the analysis of large biomolecules and revolutionizing the analysis of biological systems. Today, mass spectrometry occupies an increasingly important role, having become the technology-of-choice for proteomic analysis for both individual macromolecular components and complex biomolecular mixtures. Notwithstanding this success, there remains much room for further development of the capabilities of mass spectrometry. At present, mass spectrometry is a relatively inefficient process, in which typically only one out of 107 to 1010 molecules in a sample being
analyzed actually gives rise to a detection event. Although the resolution for low m/z species can be extremely high, at larger m/z values corresponding to low charge states of large biomolecules, biomolecular complexes, or even subcellular structures and cells, both resolution and detection efficiency are extremely poor. An important frontier for the future is addressing the chemical and instrumental issues associated with these limitations. Approaches to the design of high resolution mass spectrometers with an overall efficiency approaching unity and a very high m/z range will be presented. Such a next generation of mass spectrometers will provide new tools of unparalleled power for dissecting the biological and chemical complexity of the post-genomic era.
- Bio: Lloyd M. Smith, Travis Berggren, Xiaoyu Chen, Michael Westphal, Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI, 53706
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