This presentation will examine the benefits and shortcomings of FTICR MS for the analysis of complex mixtures. The characterization of these samples is predicated upon accurate mass measurement and the stable isotope distribution matching of all molecular ions in one mass spectrum. Further identification is afforded from accurate mass measurements of all product ions obtained from MS/MS methodologies. Although the speed of simultaneous molecular ion analysis is lost when one must isolate each molecular ion for subsequent MS/MS in turn, product ion accurate mass measurement provides an increased level of confidence in characterizing these complex mixtures. Finally, we will examine a novel method in which the multiplex advantage normally attributed to standard FTICR MS analysis is now realized in the MS/MS domain through Stored Waveform Ion Modulation (SWIM) 2D-FTICR MS such that simultaneous fragmentation of all ions is deconvoluted in an automated experiment. The final result is total assignment of product ions for each precursor ion in a mixture.
Dr. Ross served as an instructor for the American Society of Mass Spectrometry 2000 Fall Workshop on Biological FTICR MS, and was on the board of The Delaware Valley Mass Spectrometry Discussion Group from 1999-2002, which he Chaired in 2001. He is currently serving a three year term as the Chairperson for the FTICR MS Discussion Group of ASMS. In 2003, Dr. Ross was one of 5 scientists selected as a National Tour Speaker for the Society of Applied Spectroscopy. He has authored or co-authored 11 papers, given 12 invited talks, and 17 presentations at mass spectrometry meetings. In his free time, Chuck enjoys golf, bowling, darts, and the history of submarines.
This page has been accessed
times since 9/15 /96 .
Last Updated 10/16/2003