May Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
Delaware Valley Mass Spectrometry Discussion Group Vendors Meeting.
Please RSVP to Christopher Petucci by Wednesday, May 2nd.
An RSVP is needed to get a headcount for the served dinner.
ACS Philadelphia Section,
Research Scientific Services,
- Topic: "Developing IMS-IMS Analogues of MS-MS"
- Speaker:R. David Clemmer
- Date: Monday May 7, 2007. 5:00 PM
5:00-6:30 p.m. Vendor Show (door prizes: iPod shuffle, gift certificates to King of Prussia Restaurants)
6:30-7:30 p.m. Free Dinner
7:30-7:40 p.m. Business
7:40-8:45 p.m. Talk (David Clemmer)
- Please RSVP to Christopher Petucci by Wednesday, May 2nd. An RSVP is needed to get a headcount for the served dinner
- (484) 865-8377
- Place: Villanova Conference Center (Please enter through the doors to the conference center main entrance).
- Abstract: When a packet of a mixture of ions in a buffer gas is exposed to an electric field the ions separate according to differences in their mobilities. This separation is the basis for the long standing analytical technique -Ion Mobility Spectrometry (IMS). In the last ten years, developments of new ionization sources, reliable computational approaches for calculating mobilities for trial geometries, and efficient instrument designs that aim to couple IMS with mass spectrometry and liquid chromatography have led to many new IMS applications. This talk will focus on recent progress associated with developing multidimensional IMS-MS separations. An example, involving an effort to map the human plasma proteome will be given. The talk also describes the development of the first IMS-IMS instrumentation. In this approach mobility-separated ions are selected (based on their mobilities), collisionally activated and then separated again. The IMS-IMS approach is analogous in many ways with MS-MS; however, components are resolved based on differences in mobility rather than m/z. This approach offers advantages of selectivity (compared with IMS alone) and makes it possible to follow pathways associated with structural transitions.
- Bio: Professor Clemmer received a Ph.D. in Chemistry from the University of Utah and did postdoctoral work at the Himeji Institute of Technology (Japan) and Northwestern University before coming to IU in 1995. His research involves the development of methods for studying the structures of complex low-symmetry systems in the gas phase. These methods are being applied to several types of problems including elucidation of fundamental issues associated with how a protein folds, as well as studies of complex mixtures of proteins - the emerging field of proteomics. Professor Clemmer has published more than 120 papers and his work has been recognized with several awards, including the Fresenius Chemistry Award. He has been a member of the US Defense Science Study group.
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