October 2008 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Using MALDI-TOF MS to determine macromolecular structure: Investigations of a synthetic polymer chemist
- Speaker: Scott M. Grayson (Tulane University)
- Date: Monday, October 13, 2008. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to John Masucci JMASUCCI@PRDUS.JNJ.COM by Thursday Occtober 9th.
- Place: Department of Chemistry, Villanova University (Room 115, Mendel Hall)
The field of polymer chemistry has matured sufficiently to enable the assembly of complex macromolecular architectures. However, the characterization tools available to confirm structure are limited. Because of the high resolution of modern MALDI-TOF MS, mass spectral data can be used to elucidate the connectivity and reactivity of relatively complex macromolecular structures. A series of case studies will be examined in the context of designing macromolecular carriers for drug delivery.
Scott Grayson was trained as a synthetic polymer chemist, but has a genetic predisposition towards mass spectrometry. He obtaining his Ph.D. with Jean M. J. Fréchet (UC, Berkeley) and carried out a post-doctoral fellowship with C. Grant Willson (UT, Austin.) His early work investigated the synthesis and controlled degradation of dendritic polymers, with a focus on biomedical applications. Since initiating his independent research career at Tulane University, he has focused on developing improved techniques for making and characterizing cyclic polymers, to explore the applications of this unique macromolecular topology.
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