November 2009 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "When in doubt, deuterate
- Speaker: Patrick Callery, West Virginia University
- Date: Monday, November 9, 2009. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to Bill Simonsick firstname.lastname@example.org by Thursday November 5th.
- Place: Department of Chemistry, Villanova University (Room 102, Mendel Hall)
Examples of hydrogen/deuterium exchange experiments useful in solving problems in drug metabolism will be discussed. Valuable chemical structure information is often available from replacing atoms with stable isotopomers. For example, replacement of hydrogen with deuterium in a drug molecule is easily detected by mass spectrometry as an observed shift in mass. H/D exchange is a popular way of characterizing drug metabolite structures by detecting the number of exchangeable hydrogen atoms. In addition to the count, further structural information is often available from labeled product ions in multistage mass spectrometry. H/D exchange can also provide complementary information to accurate mass measurements in assigning structures to mass spectral fragment ions. Readily exchangeable hydrogen atoms are found in groups containing O-H, N-H, and S-H. Other functional groups where H/D exchange can occur at C-H bonds include enolizable groups and imine-enamine tautomers.
Born in California, Pat earned his BS degree in pharmacy at the University of Utah where his first introduction to mass spectrometry was in an instrumentation elective. He earned his PhD in pharmaceutical chemistry at the University of California San Francisco under the direction of Neal Castagnoli. His drug metabolism dissertation project included synthesis and application of deuterium labeled compounds in quantifying stereoselective enzyme reaction products using chemical ionization mass spectrometry. After a postdoctoral fellowship in medicinal chemistry, he was a professor in the pharmacy school at the University of Maryland Baltimore and active member of the Greater Washington Area Mass Spectrometry Discussion Group. He with his graduate students and post docs generated numerous manuscripts describing applications of stable isotopes to the study of drug metabolism reactions and prodrug activation. Currently, he is a professor at the West Virginia University school of pharmacy.
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