April 2010 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Opening the Box: The DART Ion Source
- Speaker: Robert B. Cody, JOEL USA, Inc.
- Date: Monday, April 12, 2010. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to Bill Simonsick firstname.lastname@example.org by Thursday April 8th.
- Place: Department of Chemistry, Villanova University (Room 102, Mendel Hall)
Until the latter part of the last century, samples to be analyzed by mass spectrometry had to be introduced into a high-vacuum ion source. Vacuum ion sources, such as electron ionization (EI) and chemical ionization (CI) and even fast atom bombarment (FAB) and matrix-assisted laser desorption are still used today. However, putting a sample into a high vacuum places severe limits on the kinds of samples that can be analyzed. The development of atmospheric-pressure ion sources such as atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) in the late 1970's and early 1980's was a major paradigm shift that led to development of modern LC/MS systems.
In late 2002 and early 2003, we constructed the direct analysis in real time (DART) source which was destined to become the first of a new generation of so-called "ambient" ion sources. Following two years of experimentation and data collection, the DART was publicly disclosed at the 2005 ASMS Sanibel Conference in the same session whered desorption electrospray ionization (DESI) was first presented. A commercial DART source was introduced two months later at the Pittsburgh Conference. Since that time, a large number of new atmospheric pressure "ambient" ion sources have been developed largely based on variations on plasma or electrospray methods.
The DART operating principle is based on the interactions of neutral excited-state atoms or molecules with the sample and/or atmospheric gases. Water vapor and oxygen in the air play an important role in the ionization mechanism.
Easy access to the "open" ion source makes the DART a very versatile way to analyze small molecules. Applications range from analysis of counterfeit drugs and contaminated products to foods, beverages and herbal supplements, synthetic chemistry and materials analysis. The DART has been adopted by government and forensic labs, as well as academic and industrial users. DART has even been featured on a popular television crime show.
Robert B. ("Chip") Cody, B received his B.S. in Chemistry (Roanoke College 1976); Ph.D. in Analytical Chemistry (Purdue University, 1982 with Professor Ben Freiser) where he developed among other things the tandem-in-time and MSn techniques that are a critical feature of all modern trapped-ion mass spectrometers. From 1982 to 1989 Dr. Cody worked at Nicolet Analytical Instruments (Madison, WI). From 1989 to the present he has worked at JEOL USA, Inc. in Peabody, MA where he is currently Product Manager for Mass Spectrometry. His present research interests include ambient ionization techniques and the software-assisted interpretation of high-resolution mass spectra of complex mixtures. He is coinventor of the Direct Analysis in Real Time (DART) ion source and is presently serving as Vice President for Arrangements for the American Society for Mass Spectrometry (ASMS). Dr. Cody is also a member of the Analytical Division of the American Chemical Society.
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