October 2010 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
PLEASE NOTE: We will meet in Mendel 154.
- Topic: "Methods to Distinguish Volatile Organic Compounds using Selected-Ion Chemical Ionization in an Ion Trap Mass Spectrometer"
- Speaker: Karen S. Wendling, Chestnut Hill College
- Date: Monday, October 11, 2010. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to Karen Wendling WendlingK@chc.edu by Thursday October 7th.
- Place: Department of Chemistry, Villanova University (Room 154, Mendel Hall)
Volatile organic compounds (VOCs) are released into the environment from both anthropogenic and biogenic sources. While mass spectrometry (MS) lends itself well to the study of VOCs and the reactions they undergo, the study of multiple VOCs simultaneously using electron ionization MS leads to complex spectra where it can be difficult to identify the individual VOCs being studied. Proton transfer reaction MS (PTR-MS) has addressed this problem using proton transfer ionization with hydronium reagent ions. VOCs are typically ionized to form the [M + H]+ species with little fragmentation. However, a fundamental limitation of PTR-MS is the study of isomeric or isobaric VOCs, which produces [M + H]+ ions having indistinguishable mass-to-charge ratios. The research described in this presentation focuses on the analysis of isomeric and isobaric VOCs using selected-ion chemical ionization (SICI) with an ion trap mass spectrometer (ITMS). In this method, reagent ions are generated in an ionization source and directed into the ITMS. Target reagent ions are then "selected" by ejecting all other ions from the ITMS. The analyte is simultaneously leaked directly into the vacuum housing where it can be ionized by chemical ionization in the mass analyzer. The utility of this method for the analysis of isomeric and isobaric VOCs is demonstrated by 1) the MSn capabilities of the ITMS, 2) the ability to ionize a specific isomer/isobar by selecting the appropriate reagent ion species, and 3) the ability to perform subsequent ion-molecule reactions to identify target isomers/isobars.
Karen S. Wendling is an Assistant Professor of Chemistry at Chestnut Hill College in Philadelphia, PA. She completed her doctoral research in Analytical Chemistry at the University of North Carolina at Chapel Hill under the guidance of Professor Gary Glish. Her graduate research involved developing new methods using selected-ion chemical ionization in an ion trap mass spectrometer. At UNC-Chapel Hill, she was the recipient of an Alfred P. Venable Fellowship, an Eastman Chemical Company Summer Fellowship in Analytical Chemistry, a Graduate Assistant in Areas of National Need (GAANN) Fellowship, and the Carol and Edward Smithwick Dissertation Completion Fellowship. She was also named to the Royster Society of Fellows and completed the Preparing Future Faculty Fellowship Program. Karen has presented her research at local and regional mass spectrometry conferences as well as at the American Society for Mass Spectrometry (ASMS) national meetings. Since joining the faculty at Chestnut Hill College, Karen has participated in several collaborations at Temple University, most recently as a visiting researcher in Dianne Soprano's laboratory at the School of Medicine. Karen's most recent publication was as a co-author in The Journal of Neurosurgical Anesthesiology (October, 2008).
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