May Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
Delaware Valley Mass Spectrometry Discussion Group Vendors Meeting.
Please RSVP to Karen Wendling - firstname.lastname@example.org - by Wednesday, May 4th, 2011.
An RSVP is needed to get a headcount for the served dinner.
ACS Philadelphia Section,
Critical Path Services,
Research Scientific Services,
Scientific Instrument Services,
- Topic: "Innovative Developments Which Broaden the Role of Mass Spectrometry "
- Speaker:Jack Henion
- Date: Monday May 9, 2011. 5:00 PM
5:00-6:30 p.m. Vendor Show (door prizes: American Express Gift Certificates)
6:30-7:30 p.m. Free Buffet-Style Dinner
7:30-7:40 p.m. Business (Election of Officers, etc
7:40-8:45 p.m. Talk (Jack Henion)
- Please RSVP to Karen Wendling by Wednesday, May 4th. An RSVP is needed to get a headcount for the served dinner
- (215) 248-7080
- Place: Villanova Conference Center (Note: this is NOT on the Villanova University campus).
Please note: If you are using a GPS locater, please enter 629 County Line Road, Radnor, PA 19087 or Latitude 40.05 and Longitude -75.35.
- Abstract: Mass spectrometry has come a long way since the early days of organic mass spectrometry of the 50's and 60's. Electron ionization (EI) from a solid probe or 'hot box' inlet was followed by chemical ionization (CI) with similar sample introduction. Then GC/MS evolved with both of these ionization modes for handling complex mixtures. Qualitative analysis by MS was followed by quantitative analysis using selected ion monitoring (SIM) which was driven by environmental applications. In the late 70's we began to see attempts to accomplish LC/MS which attempted to employ EI and CI but which lost out to thermospray, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). These techniques have survived the test of time with true analytical value by being implemented throughout the pharmaceutical industry as well as applications in industrial chemistry, environmental chemistry, food safety and more recently clinical chemistry. Throughout these developments applications have driven the progress with success measured by the productive solution of real-world problems.
Improvements and expanded applications continue to evolve which broaden the utility of mass spectrometry which places this amazing technology in the hands of established as well as new users. This presentation will describe additional new developments which further increase the field of use for mass spectrometry. These include developments in miniaturized devices which lead to nanoscale chromatography with concomitant increases in sensitivity, automation which is amenable to applications of surface sampling of dried blood spots as well as food surfaces to detect pesticides and the profiling of animal organs for drug and metabolite distributions across the various organs within a thin tissue slice. As an added example mass spectrometers have the potential to be collocated within a medicinal chemistry laboratory adjacent to a synthetic reaction for real-time reaction monitoring to optimize a chemical synthesis. These and related examples will be presented which demonstrate the relevance of the lecture title.
- Bio: Jack Henion, Ph.D. Emeritus Professor, Cornell University and CSO, Advion BioSciences, Inc., Ithaca, NY 14850.
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