October 2011 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
PLEASE NOTE: We will meet in Mendel 154.
- Topic: "Emerging Flow Injection Mass Spectrometry Methods for High-Throughput Quantitative Analysis "
- Speaker:Sergio C. Nanita, DuPont Co
- Date: Monday, October 10, 2011. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to Eric Manning firstname.lastname@example.org by Thursday October 6th.
- Place: Department of Chemistry, Villanova University (Room 154, Mendel Hall)
Improvements in sensitivity and ruggedness of mass spectrometry (MS) over the past decade have increased the use of MS as stand-alone technique for high-throughput chemical analysis and encouraged the development of novel sample introduction methods like ambient ionization. Other sample introduction techniques are re-emerging as useful tools for direct MS analysis, including flow injection (FI), filling a gap that exists in methods for trace-level analysis in complex systems. FI-MS increases throughput compared to conventional HPLC/MS without notably compromising analytical figures of merit (e.g. precision, accuracy, ruggedness, extraction efficiency) as is sometimes the case in methods employing ambient ionization.
The DuPont Company, as part of an internally-funded research project, has developed widely-applicable FI-MS methods for trace-level analysis with 15-second instrument run times per sample. The methods have been tested for quantitation of pesticides in a variety of complex matrices: (i) citrus, corn, nuts, cooking oil, processed cereals, milk, and eggs, demonstrating applicability for food safety monitoring and agricultural research; (ii) cotton fabric for estimation of worker exposure; (iii) blood plasma and urine to demonstrate method capability in bio-analysis. These methods have been successfully validated for quantitative screening using MS/MS (multiple reaction monitoring, MRM) with limits of detection at or below 20 ng/g (parts-per-billion) for more than a dozen agrochemical active ingredients. In addition, FI-MS methods have been tested by DuPont for screening of small molecules in chemical genomics research, and for high-throughput quantitation of chemicals in industrial waste. Example methods and results from 3 facilities across U.S.A. will be presented. The outlook of the technique will be reviewed together with FI-MS methods recently developed/published by government agencies, universities, and private companies.
Sergio Nanita is a mass spectrometrist known at DuPont for his innovative methods for rapid detection of chemicals in the most complex systems. He was born in Santo Domingo, Dominican Republic, earned a B.S. in chemistry from the University of Puerto Rico (Río Piedras) in 2001 and a Ph.D. in analytical chemistry from Purdue University in 2005. He joined DuPont as a principal investigator immediately after graduate school. Dr. Nanita’s research program at DuPont has led to the development of novel high-throughput methods for pesticide residue analysis. Extended applications of his methods have proven useful to address challenges in agricultural chemistry, environmental sciences, food safety, and forensic sciences. His work is inspiring scientists to improve analysis throughput and operational efficiency of laboratories around the world. At DuPont Crop Protection, Dr. Nanita has led several analytical chemistry projects that support the development of novel agricultural products, their registration and launch into global markets to address the need for increased food production. He has authored 20 peer-reviewed publications and given lectures at several universities, conferences, and private companies across U.S.A. and Latin America in English and Spanish. He currently volunteers as a science writer for the ACS Puerto Rico Local Section and El Nuevo Dia (newspaper) as part of the International Year of Chemistry (IYC).
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