February 2012 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
PLEASE NOTE: We will meet in Mendel 154.
- Topic: "New Ionization Approaches in Mass Spectrometry and How They Might Work"
- Speaker:Charles N. McEwen, The University of the Sciences
- Date: Monday, February 13, 2012. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to Eric Manning email@example.com by Thursday February 9th.
- Place: Department of Chemistry, Villanova University (Room 154, Mendel Hall)
Mass spectrometers have become extremely sophisticated with unprecedented mass resolution, mass accuracy, and fragmentation capabilities. Sample preparation, separations, and ionization are also well developed. Nevertheless, our understanding of ionization processes in mass spectrometry has scarcely improved in the last 25 years. The recent finding that a MALDI matrix/analyte preparation when placed in a heated inlet tube linking atmospheric pressure with vacuum conditions produces electrospray like ionization has provided a window to better appreciate mechanistic aspects of ionization of nonvolatile compounds. In this presentation, applications of laserspray ionization (LSI), matrix assisted inlet ionization (MAII), and solvent assisted inlet ionization (SAII) will be presented as well as how the lessons learned from these processes allowed the first production of highly charged ions under vacuum MALDI conditions. The mechanistic implications of these findings to ionization processes in ESI, MALDI, inlet ionization, and other ionization methods capable of transferring nonvolatile compounds to the gas phase as ions will be discussed.
Charles N. McEwen is currently the Houghton Professor of Chemistry & Biochemistry at the University of the Sciences. Prior to moving to an academic position in 2008, he worked in the DuPont Central Research Department for 35 years as a manager and as a research scientist. Chuck received his B.S. degree in Chemistry from the College of William and Mary, an M.S. from Atlanta University, and a Ph.D. degree in Chemistry from the University of Virginia under the supervision of Donald Hunt. Much of his more recent research has involved fundamental studies related to ionization methods for mass spectrometry. He was the first to recognize the potential of GC/APMS and atmospheric solids analysis probe (ASAP) applied to LC/MS instruments. Both methods are now commercially available. The current focus of his research is on inlet ionization methods comprising laserspray ionization (LSI), matrix assisted inlet ionization (MAII), and solvent assisted inlet ionization (SAII). Chuck has over 100 publications, including co-edited and co-authored books on mass spectrometry. .
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