May Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
Delaware Valley Mass Spectrometry Discussion Group Vendors Meeting.
Please RSVP to Eric Manning - email@example.com - by Wednesday, May 9th, 2012.
An RSVP is needed to get a headcount for the served dinner.
ACS Philadelphia Section,
Critical Path Services,
Research Scientific Services,
Scientific Instrument Services,
- Topic: "The New Tandem MS: Ion Mobility Spectrometry/Mass Spectrometry"
- Speaker:Gary L. Glish, University of North Carolina
- Date: Monday May 14, 2012. 5:00 PM
5:00-6:30 p.m. Vendor Show
6:30-7:30 p.m. Free Buffet-Style Dinner
7:30-7:40 p.m. Business (Election of Officers, etc)
7:40-8:45 p.m. Talk (Gary Glish)
- Please RSVP to Eric Manning by Wednesday, May 9th. An RSVP is needed to get a headcount for the served dinner
- (610) 310-3484
- Place: Villanova Conference Center (Note: this is NOT on the Villanova University campus).
Please note: If you are using a GPS locater, please enter 629 County Line Road, Radnor, PA 19087 or Latitude 40.05 and Longitude -75.35.
- Abstract: Tandem mass spectrometry (MS/MS) is one of the most powerful methods available to the modern analytical chemist. However, as instruments become more and more sensitive there is an increasing challenge of isomeric and isobaric ions interfering with the analysis. The conventional approach to overcoming this problem is to use liquid chromatography (LC) to separate analytes prior to ionization. While LC is a powerful analytical technique in its own right, it has some limitations when combined with mass spectrometry. A couple of important limitations are that the time frame of an LC separation is much slower than mass spectrometry (minutes vs. seconds or less), and the order of analyte analysis cannot be adjusted in real-time. And for some applications such as real-time analysis of aerosols, LC is not even an option.
As an alternative to chromatography separations, we are developing differential ion mobility spectrometry (DIMS) as a separation method prior to MS/MS. While mass spectrometry separates ions based on their mass-to-charge ratio, ion mobility separation is based on the ions' shape-to-charge ratio. DIMS has significant differences compared to the more conventional drift tube ion mobility that make DIMS more useful as an alternative to chromatography when combined with MS. In this presentation the fundamentals of DIMS will be discussed. Examples will be shown using DIMS/MS to analyze isobaric peptides, aerosols in real-time, and targeted compounds in complex matrices.
- Bio: Gary Glish was a Chemistry and Economics major at Wabash College, graduating in 1976. He earned a Ph.D. from Purdue University, under the direction of Graham Cooks in 1980. Part of his dissertation work at Purdue involved building the first hybrid mass spectrometer (BqQ) for analytical MS/MS. He has spent the subsequent 30+ years wandering through the wonderland of mass spectrometry instrumentation. During his 12 years at Oak Ridge National Laboratory he invented the Q-TOF, built a positron ionization mass spectrometer which used an electron accelerator for part of the ion source, and did early work with quadrupole ion traps. He continued doing work with quadrupole ion traps when he went to The University of North Carolina in 1992 and has been involved with numerous other types of mass spectrometry instrumentation and the study of fundamentals of MS/MS.
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