In 2005 Coon began his independent career as an Assistant Professor of Chemistry and Biomolecular Chemistry at the University of Wisconsin, Madison. He was promoted to Associate Professor in 2009 and Full Professor in 2012. At Wisconsin Coon has continued to develop ETD and other proteomic technologies. One significant achievement of Coon's group was the coupling of ETD to the orbitrap mass analyzer. The high mass accuracy and resolving power of the orbitrap analyzer greatly extends and facilitates the utility of ETD. Thermo Fisher Scientific commercialized Coon's implementation in 2007. By 2008, Coon's technology began to reach researchers across the globe. Today several hundred of these systems are in use worldwide, with about 1 of every 2 orbitrap mass spectrometers including ETD hardware. Because of this rapid technological development and its utility, publications involving the use of ETD continue to rise with nearly 120 published in 2010.
Coon has presented over 150 invited lectures in the past five years and his publications (~80) have received over 4,000 citations since 2005. His scientific impact, creativity, and vision is evinced by several high profile honors including: Beckman Young Investigator, Eli Lilly and Company Young Investigator, the Ken Standing Award, the Pittsburgh Conference Achievement Award, the Arthur F. Findeis award (ACS), the Biemann Medal (ASMS), among others. Coon is an inventor of 10 U.S. and foreign patents and his research is funded by Federal, private, and non-profit sources. Indeed, Coon's research, by many metrics, has had a broad and transformative impact. Coon seeks to continue developing next-generation protein measurement technologies along with integrated informatics platforms for assimilating protein data with gene- and transcript-level figures.
Coon's forward looking goal is to use these technologies, and others to be developed, to empower biological researchers, with their sundry models and samples, through advancements in technology, systems data integration and analysis tools, and access. Global protein quantification methodologies, either relative or absolute, are not routine, even for expert laboratories. The result is highly rationed access to arguably the most valuable and telling type of systems level data. Coon aims to catalyze and expedite this transformation in quantitative biology.
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