November 2012 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
PLEASE NOTE: We will meet in Mendel 154.
- Topic: "Structure Elucidation through the use of FTICR, Accurate Mass Measurement, and MSn Methodologies"
- Speaker:Charles Ross, Merck
- Topic: "Open-Access LC/MS in Research at Merck"
- Speaker:Vincent Van Nostrand , Merck
- Date: Monday, November 12, 2012. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to Sergio Nanita email@example.com by Thursday November 8.
- Place: Department of Chemistry, Villanova University (Room 154, Mendel Hall)
Structure Elucidation through the use of FTICR, Accurate Mass Measurement, and MSn Methodologies.
With the increased use of open access analytical instrumentation such as LCMS and NMR, the synthetic chemist may quickly survey their reactions and products. Also, combinatorial chemistry and high throughput automated synthesis provides more compounds in less time. As such, the possibility of side products and unknowns also increases. In this presentation, the use of accurate mass measurement and MSn by FTICR MS will be discussed in characterizing these compounds.
Open-Access LC/MS in Research at Merck.
Open-Access LC/MS systems have become popular in recent years thanks to the ease of use of the walk-up software available from many vendors. At Merck, open-access LC/MS was introduced in research in the late 1990's and has evolved to an efficient and reliable global network of instrumentation. The development of the global open-access LC/MS network, as it is used today, has taken into account the best practices from each site. Using a standard set of rules, responsibilities, and methods, the data generated at all of the Merck research sites is consistent, which helps chemists to share data and aids decision making throughout the lifecycle of drug candidates.
Charles W. Ross III, born in Lakemore Ohio, graduated from The University of Akron in 1988 with his B.S. in Chemistry. He specialized in environmental analytical chemistry under the advisement of Prof. James K. Hardy, and received a letter of commendation from the Village of Lakemore for his heavy metal pollutant analysis of Springfield Lake. He earned his Ph.D. in Analytical Chemistry - Mass Spectrometry with Professor Alan G. Marshall in 1993 at The Ohio State University. His dissertation focused on gas phase reactions of carbenes and new methods to characterize complex mixtures by Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS). After an appointment at the National High Magnetic Field Laboratory - Tallahassee, FL, Chuck spent 1995 as a visiting scientist at DuPont Automotive Finishes - Marshall Research Laboratories in Philadelphia, PA. During this time, he conducted research in coatings technology, and polymeric analysis with Dr. William J. Simonsick Jr. In 1996, Chuck joined the Research Mass Spectrometry Laboratory (RMSL) - Department of Medicinal Chemistry, Merck & Co. Inc. West Point, PA headed by Dr. Harri Ramjit. He was promoted to Senior Research Fellow and head of the RMSL facility in 2005, and is currently Director, Chemistry and the MS lead for the Global Structure Elucidation Group, consisting of high level MS and NMR analysis.
Building upon his expertise in FTICR MS and complex mixture analysis, Chuck's work focuses on characterizing targeted compounds, unknown by-products, and complex mixtures by use of accurate mass measurement and MS/MS methodologies.
Dr. Ross has served as:
He has authored or co-authored 21 papers, given 16 invited talks, and 17 presentations at mass spectrometry meetings. Chuck enthusiastically mentors and develops scientists. In his free time, he enjoys golf, bowling, darts, college football, and the history of submarines.
- Instructor for the American Society of Mass Spectrometry 2000 Fall Workshop on Biological FTICR MS,
- Boardmember of The DVMSDG from 1999-2002, which he Chaired in 2001,
- Chairperson of The FTICR MS Discussion Group of ASMS, 2002-2004,
- Selected as a National Tour Speaker for the Society of Applied Spectroscopy, 2003.
- Guest Lecturer - University of the Sciences in Philadelphia 2005-2012.
- Instructor - 2012 SMASH NMR Conference Workshop: Mass Spectrometry for NMR Spectroscopists.
Vincent Van Nostrand graduated from Towson University in 2000 with a B.S. in Chemistry. He focused on Biochemistry and was the recipient of various academic awards, including the Floyd Blankenship Memorial Award in Physical Chemistry and the ACS Division of Polymer Chemistry Outstanding Achievement in Organic Chemistry. While working in the Pharmaceutical Analysis and Control department at Merck, where he was involved in the publication of numerous journal articles focused on the use of Visible Residue Limit in Cleaning Validation of pharmaceutical manufacturing equipment, Vince earned his M.S. in Analytical Chemistry under Dr. Cathy Bentzley at University of the Sciences in Philadelphia in 2005. His research project focused on a medical application for the SWIM 2D-FTMS work of Dr. Charles W. Ross, III. After meeting Chuck during his graduate studies, Vince joined the Research Mass Spec Lab in Medicinal Chemistry at Merck, where he has been managing the Open-Access LC/MS network and running research samples since 2005. Vince has also served as the Treasurer for the DVMSDG. Outside of work, Vince can often be found riding local mountain bike trails or riding his couch, as he plays video games and watches movies.
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