May Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group

Delaware Valley Mass Spectrometry Discussion Group Vendors Meeting.

Please RSVP to Sergio Nanita - Sergio.c.nanita@usa.dupont.com - by Tuesday, May 7th, 2013.
An RSVP is needed to get a headcount for the served dinner.

• Topic: "RAPID TARGETING OF STRUCTURE IN COMPLEX MIXTURES; Recognizing Disease Through Molecular Signatures"

• Speaker:Fred Regnier, Purdue University

• Date: Monday May 13, 2013. 5:00 PM

• Time: 5:00-6:30 p.m. Vendor Show
  6:30-7:30 p.m. Free Buffet-Style Dinner
  7:30-7:40 p.m. Business (Election of Officers, etc)
  7:40-8:45 p.m. Talk (Fred Regnier)

• Please RSVP to Sergio Nanita by Tuesday, May 7. An RSVP is needed to get a headcount for the served dinner
  1. Sergio.c.nanita@usa.dupont.com
  2. (302) 451-5806

• Place: Villanova Conference Center (Note: this is NOT on the Villanova University campus).
• Directions:http://www.acc-villanovaconferencecenter.com/villanova-conference-center-en.html

  Please note: If you are using a GPS locater, please enter 629 County Line Road, Radnor, PA 19087 or Latitude 40.05 and Longitude -75.35.

• Abstract: Life, health, and disease can be defined by molecular signatures; often involving small numbers of unique molecules within a background of thousands, to several hundred thousand very similar species. Having invested heavily for decades in recognition and validation of disease signatures it is now time to translate these findings into methods that allow rapid assessment of health and disease. How that might be done will be the focus of this presentation.

  Mass spectrometry (MS) has become the darling of these efforts; the premise being that bigger, faster, higher resolution MS instruments can solve anything. But before becoming a carpenter with a magic hammer, it is worth looking at the nails we are trying to drive. The structure of many “biomarkers” for example has only been inferred by the presence of an ion. It is probably necessary to define the structure of the parent molecule from which the ion was derived. A second problem is in showing that molecular features targeted by analytical systems are either the same or co-reside with structural features that signifying disease. They may not associated. Being able to show that “analytical features” and “biological activity” of molecules are connected by multiple, high selectivity means is essential. A third problem is how to deal with the fact that sample complexity can exceed the limits of analytical tools. How separation systems can be used to reduce sample complexity, achieve targeted multiplexing, enhance detection sensitivity, and increase the confidence of identifications will be addressed. Finally there is the problem that MS can identify biomarkers in msec while sample preparation takes hours. This is a serious limitation not solved by large scale parallel processing. Early studies focusing on solutions to sample preparation will be presented. Finally, it will be suggested in conclusion that the ability to target multiple structures will be a dominant issue in the future of life science oriented separation systems.

• Bio:
Dr. Fred E. Regnier is a Distinguished Professor of Chemistry at Purdue University. He is generally regarded as one of the world authorities on proteomics. Additionally, he is an accomplished entrepreneur, cofounding several companies such as BioSeparations, PerSeptive Biosystems, Beyond Genomics, Novilytic, and Perfinity Biosystems. He also serves on the Boards of several companies. He has published more than 300 journal articles and 70 book chapters and reviews, has more than 40 patents, has edited two books, and has won numerous national and international awards and distinctions for his research in analytical chemistry and biochemistry. Dr. Regnier received his B.S. from the Nebraska State College and holds a Ph.D. from Oklahoma State University. He did his postdoctoral training at the University of Chicago and Harvard University under the direction of John H. Law and Edward O. Wilson, respectively.

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Last Updated April 10, 2013