November 2013 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
PLEASE NOTE: We will meet in Mendel 115.
- Topic: "Mass Spectrometry in Food Safety"
- Speaker: John H. Callahan, Acting Deputy Director, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, FDA, College Park, MD
- Date: Monday, November 11, 2013. 6:30 PM
- Time: Social Hour: 6:30 PM.
Talk: 7:30 PM.
Please RSVP to John Masucci JMasucci@its.jnj.com by Thursday November 7.
- Place: Department of Chemistry, Villanova University (Room 115, Mendel Hall)
The FDA's regulatory activities affect approximately 20% of every consumer dollar spent, with food safety being an important part of the FDA's regulatory purview. The Center for Food Safety and Applied Nutrition (CFSAN), along with the FDA's field laboratory structure under the Office of Regulatory Affairs (ORA), are chiefly responsible for the FDA food safety mission. Foods-related areas of regulatory concern include beverages, color and food additives, dairy products, dietary supplements, food ingredients, food packaging, game meat, grain-based products, infant formula, medical foods, plant products, seafood, spices, and cosmetics. The detection of contaminants and adulterants in foods is a major analytical challenge for the FDA, and as mass spectrometry has become central to analytical chemistry, it has also assumed a critical role in the FDA's food safety methods. In this presentation, I will highlight some of the areas where mass spectrometry has had, and will increasingly have, an impact on methods for food safety. One area that will be addressed is the development of non-targeted screening methods, based on high-resolution mass spectrometry, to enhance the FDA's capability to detect intentional and unintentional adulteration of foods. The role of liquid chromatographic separations, mass resolution and mass accuracy in non-targeted methods will be addressed. I will also discuss the development of mass spectrometry-based methods for the detection and quantification of allergens in foods, and will highlight some of the elements of the problem, including extraction of proteins from complex matrices, the role of liquid chromatography, and the difficulties associated with internal standardization and quantification.
John Callahan was born in Denver, CO and received a bachelor's degree in Chemistry from The Colorado College in Colorado Springs, CO. He received his Ph.D. in Analytical Chemistry under the direction of Kelsey Cook at the University of Illinois, Urbana-Champaign, where his thesis was on Electrohydrodynamic Ionization Mass Spectrometry. After a National Research Council post-doctoral fellowship at the U.S. Naval Research Laboratory (NRL), he joined the staff at NRL as a research scientist and later served as section head for the Mass Spectrometry and Analytical Chemistry Sections. His work at NRL focused on basic and applied applications of mass spectrometry, and included fundamental studies of carbon clusters, the development of MS methods for the study of biomolecules, and the analysis of volatile organic compounds in the enclosed atmospheres of U.S. Navy nuclear submarines. He joined the FDA's Center for Food Safety and Applied Nutrition (CFSAN) in 2003 as a staff scientist, and has served as the Branch Chief for the Spectroscopy and Mass Spectrometry Branch (SMSB) since 2005. Work in SMSB is focused on the development of methods for the analysis of marine toxins, allergens, and protein toxins in foods, the development of high-throughput untargeted screening methods and the application of advanced spectroscopic methods for foods analysis. He is temporarily serving as acting Deputy Director of the Office of Regulatory Science at CFSAN. John has been a member of the American Chemical Society since 1979, served as the Chair of the Analytical Division of the ACS in 2005, and served on the Analytical Division Executive Committee from 2004-2007. He has been a member of the American Society for Mass Spectrometry since 1984 and served as the ASMS Board Member At-Large for Education from 2008-2010. He has been associated with the Washington-Baltimore Mass Spectrometry Discussion Group in one way or another since 1986.
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