March 2014 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
PLEASE NOTE: We will meet in Mendel 154.
- Topic: "Application of Particle Matrices in Mass Spectrometry Imaging"
- Speaker: Shelley N. Jackson, National Institute on Drug Abuse, Intramural Research Program
- Date: Monday, March 10, 2014. 6:00 PM
- Time: Social Hour: 6:00 PM.
Talk: 7:00 PM.
Please RSVP to John Masucci JMasucci@its.jnj.com by Thursday March 6.
- Place: Department of Chemistry, Villanova University (Room 154, Mendel Hall)
- Abstract: Mass spectrometry imaging (MSI) is a valuable tool for analysis and tracking of biomolecules in tissue. Tissue preparation for MALDI imaging, almost exclusively uses traditional organic matrices, such as CHCA and DHB, both weak organic acids. Matrix deposition is the key step in MALDI MSI. Ideally, this step should be relatively dry, uniform, and reproducible, which can be quite challenging using traditional organic matrices. The use of particle matrices can overcome some of these problems. However it is not widespread. We have investigated several types of particle matrices, including gold, silver, and carbon, for MALDI MSI. We also tested several ways to coat tissue with particle matrices, such as ink jet printing, spraying, and implantation. The advantages of particle matrices compared to organic matrices will be presented for a wide range of imaging experiments. The implantation of silver nanoparticles will be highlighted especially for disease models such as traumatic brain injury and alcohol abuse.
- Bio: Shelley Jackson was born in Montgomery, Al and received a B.S. in Biology (1997) from the University of South Carolina. He received a Ph.D. in Chemistry (2004) from Emory University under the direction of Kermit Murray. Next, he did a three year postdoctoral fellowship in the Structural Biology Unit at the National Institute on Drug Abuse Intramural Research Program in Baltimore, MD in Amina Woods' lab. After which he accepted his current position as a Staff Scientist in the Structural Biology Unit at NIDA IRP. His work at NIDA has focused on the analysis of lipids and drugs of abuse in biological matrixes such as tissue and plasma using ESI-MS, MALDI-MS, and ion mobility MS. Dr. Jackson has published 46 peer reviewed articles and written four book chapters. He is a member of the American Society of Mass Spectrometry and the Greater Washington Baltimore Mass Spectrometry Discussion Group (WBMSDG), which he served as the co-chair for between 2010-2012.
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