May Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
Delaware Valley Mass Spectrometry Discussion Group Vendors Meeting.
Please RSVP to John Masucci JMasucci@its.jnj.com - by Tuesday, May 6th, 2014.
An RSVP is needed to get a headcount for the served dinner.
DVMSDG Sponsors
ACS Philadelphia Section,
AB Sciex,
Agilent,
Bruker,
Critical Path Services,
Ionics Mass Spectrometry,
JRF America,
JEOL,
Keystone Bioanalytical,
Perkin Elmer,
Phenomenex,
Research Scientific Services,
Restek,
Shimadzu,
Thermo Fisher,
Waters Corporation.
- Topic: "Designer Tools for Proteomics and Glycomics: Isobaric Tags, Cross Linkers, and Sequencing Reagents"
- Speaker:Jack Beauchamp, California Institute of Technology
- Date: Monday May 12, 2014. 5:00 PM
- Time:
5:00-6:30 p.m. Vendor Show
6:30-7:30 p.m. Free Buffet-Style Dinner
7:30-7:40 p.m. Business (Election of Officers, etc)
7:40-8:45 p.m. Talk (Jack Beauchamp)
- Please RSVP to John Masucci JMasucci@its.jnj.com - by Tuesday, May 6th, 2014.
An RSVP is needed to get a headcount for the served dinner.
- Place: Villanova Conference Center (Note: this is NOT on the Villanova University campus).
- Directions:http://www.acc-villanovaconferencecenter.com/villanova-conference-center-en.html
Please note: If you are using a GPS locater, please enter 629 County Line Road, Radnor, PA 19087 or Latitude 40.05 and Longitude -75.35.
- Abstract: Glycans, whose structures are not templated, are one of the four major families of structurally related macromolecules that comprise living organisms, along with nucleic acids, proteins, and lipids. However, unlike DNA, RNA, and proteins, which possess linear structures comprising a limited number of subunits with defined stereochemistry, glycans may exhibit incredibly complicated branched structures with a large number of subunits having both structural and stereochemical diversity. We have developed a toolbox of biomimetic reagents that use a combination of acid-base and free radical chemistry which, combined with high performance mass spectrometry, are enabling for structural glycobiology. These studies build on our earlier development of novel reagents for proteomics investigations, including inexpensive and versatile isobaric tags for protein quantification, "clickable" cross linking reagents for structural studies of proteins and protein complexes, and free radical initiated peptide sequencing reagents.
References
1. Biomimetic Reagents for the Selective Free Radical and Acid?Base Chemistry of Glycans: Application to Glycan Structure Determination. Jinshan Gao, Daniel A. Thomas, Chang Ho Sohn and J.L. Beauchamp, J. Am. Chem. Soc., 135, 10684-10692 (2013).
2. Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions. Chang Ho Sohn, Heather D. Agnew, J. Eugene Lee, Michael J. Sweredoski, Robert L.J. Graham, Geoffrey T. Smith, Sonja Hess, Gregg Czerwieniec, Joseph A. Loo, James R. Heath, Raymond J. Deshaies and J. L. Beauchamp, Anal. Chem. 84, 2662-2669 (2012).
3. Click Chemistry Facilitates Formation of Reporter Ions and Simplified Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein Quantification. Chang Ho Sohn, J. Eugene Lee, Michael J. Sweredoski, Robert L.J. Graham, Geoffrey T. Smith, Sonja Hess, Gregg Czerwieniec, Joseph A. Loo, Raymond J. Deshaies and J. L. Beauchamp, J. Am. Chem. Soc., 134, 2672-2680 (2012).
4. Bioconjugates for Tunable Peptide Fragmentation: Free Radical Initiated Peptide Sequencing (FRIPS). Robert Hodyss, Heather A. Cox, and J.L. Beauchamp, J. Am. Chem. Soc., 127, 12436-12437 (2005).
- Bio:
Professor Beauchamp was an undergraduate at the California Institute of Technology, graduating with honors in 1964. His Ph.D. studies at Harvard University, under the direction of Professor John Baldeschwieler, were completed in 1967 with a thesis entitled "Ion Cyclotron Resonance Spectroscopy." He has been a faculty member of the Division of Chemistry and Chemical Engineering at the California Institute of Technology since 1967 and now holds the position of Mary and Charles Ferkel Professor of Chemistry. Professor Beauchamp's major scientific contributions have involved the development of new techniques for studies of the structures, reaction dynamics, and properties of organic, inorganic and biological molecules and ions in the gas phase. Current research efforts include development of novel reagents and methods for proteomics (e.g. cross linking reagents and isobaric tags) and glycomics (biomimetic reagents for glycan and glycoprotein structure analysis), studies of the detailed mechanism of electron capture and electron transfer dissociation, investigations of reaction dynamics at gas-liquid interfaces, studies of the structure and reaction dynamics of small molecular clusters, and an examination of the chemistry of Titan's atmosphere and surface. In 1978 he received the Pure Chemistry Award of the American Chemical Society and in 1981 was elected to the National Academy of Sciences. In 1999 he received the Peter Debye Award in Physical Chemistry from the American Chemical Society and was again honored in 2005 with the Field and Franklin Award in Mass Spectrometry. In 2007 he received the Distinguished Contribution Award from the American Society for Mass Spectrometry. He is the author/coauthor of over 300 research publications (www.jlb.caltech.edu). As an active pilot, he has a special interest in aviation safety, serving in 1996-97 on the White House Commission for Aviation Safety and Security, chaired by Vice President Gore and chairing the Committee on Commercial Aviation Security of the National Academy of Sciences. He shares an enthusiasm for camping, fishing, skiing and flying with his wife, Patricia (also a pilot), and their five children.
Please send any comments, corrections, or suggestions to
svanbram@science.widener.edu.
This page has been accessed
times since 9/15 /96 .
Last Updated April 10, 2013