November 2015 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
NOTE: WEDNESDAY MEETING
NOTE: Parking behind Mendel Hall will not be possible until later next year due to construction. In the meantime, attendees should park in the Main lot on Lancaster Pike across from the University or in the Law School parking lot.
- Topic: "Direct Analysis Methods and Miniature Mass Spectrometry Systems for Drug Development and Point-of-Care Analysis
- Speaker:Zheng Ouyang, Weldon School of Biomedical Engineering, Purdue University
- Date: Wendesday, November 11, 2015. 6:00 PM
- Time: Social Hour: 6:00 PM.
Talk: 7:00 PM.
- Place: Department of Chemistry, Villanova University (Mendel 115 , Mendel Hall)
Mass spectrometry (MS) analysis has been widely applied for drug development and clinical analysis. The traditional method of quantitation using MS analysis relies on the sample preparation, chromatographic separation and MS/MS analysis. In our research, we intend to develop miniature MS systems that operate with extremely simple protocols for the use by biologists or clinicians. The underlying technical platform is supported by the development of the ambient ionization methods and the miniaturization of mass spectrometers. Sample cartridges are developed for direct quantitation of drugs in blood or urine samples collected using minimally invasive sampling methods. Integrated desktop MS systems have also been developed. The potential of the miniature MS systems in preclinical and clinical studies as well as other point-of-care applications will be elaborated with examples.
Zheng Ouyang obtained his B.E. (1993) and M.E. (1995) in Automation at Tsinghua University, M.S. (1997) in Physical Chemistry in West Virginia University, and Ph. D. (2002) in Analytical Chemistry at Purdue University. He joined the Weldon School of Biomedical Engineering at Purdue as an Assistant Professor in 2007 and was promoted to Associate Professor in 2012 and Professor in 2015. His research interests including the fundamental studies in mass spectrometry instrumentation and analytical methods and the device development for clinical analysis. His research has been supported by NSF, NIH, NASA, DOD and industrial sponsors. He has published more than 120 peer-reviewed manuscripts and has been granted 25 patents. He received a number of awards including the NSF Early Career Award, Coulter Foundation Early Career Award for Translational Research, American Society of Mass Spectrometry Research Award, and the International Mass Spectrometry Foundation Curt Brunnee Award for outstanding contribution to mass spectrometry instrumentation.
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