January 2016 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
NOTE: Parking behind Mendel Hall will not be possible until later next year due to construction. In the meantime, attendees should park in the Main lot on Lancaster Pike across from the University or in the Law School parking lot.
- Topic: "Application of Ion Trap Gas-Phase Ion-Molecule Reaction for the Metabolite Identification
- Speaker:Minli Zhang, DuPont Stine-Haskell Research Center
- Date: Monday, January 11, 2016. 6:00 PM
- Please RSVP to Yang.Yuan@dupont.com by Thursday January 7.
- Time: Social Hour: 6:00 PM.
Talk: 7:00 PM.
- Place: Department of Chemistry, Villanova University (Mendel Hall 154)
The efficiency of metabolite structure elucidation has significantly improved in the past decades by the advances of analytical technology. The use of UPLC, the FT MS with MSn or MSe fragmentation capability and data mining software, the high resolution NMR, the radioactive or stable isotope tracers, and the synthetic chemistry support have enabled a rapid turnaround time in metabolite profile and structure identification in order to keep up the pace with an increasingly large volume of chemistry output and shortened design-make-test cycle time in drug discovery. However, challenges remain in metabolite structure elucidation. For example, the LC/MS analysis of small and polar metabolites is intrigue because of the difficulty in chromatographic separation and ion interferences in the low mass region; in the early stages of drug discovery without radio labeled compounds, some unusual metabolites may have been overlooked; metabolites that are unstable are difficult for isolation and synthesis. This presentation will discuss strategies applied to structure elucidation to overcome these difficulties, especially the utilization of gas phase ion-molecule reactions in the ion trap mass spectrometer to characterize unknown structure functionalities.
Minli Zhang is currently a Principal Investigator at DuPont in the Stine-Haskell Research Center. Minli started his career at DuPont in mid 90s. He later joined AstraZeneca and worked there for almost 15 before rejoined DuPont. He earned his PhD degree from University of California at Berkeley and did his postdoctoral research at Cornell University.
Minli spent majority part of his career in the drug metabolism and pharmacokinetics, especially, the identification of unknown metabolites and determination of the potential risks associated with the formation of reactive intermediates. His research at DuPont is focused on understanding the environmental fate and the risks of crop protection products. Comparing the drug metabolism with the agrochemicals environmental fate studies, Minli appreciates more for the complexity and challenge of environmental fate and risk assessments studies because they involve multiple matrices and varieties of targets from microorganism, plants, invertebrate, avian, to mammals and human.
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