March 2016 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Using Mass Spectrometry to Study Cell Signaling in Neurons
- Speaker:Thomas A. Neubert, New York University School of Medicine
- Date: Monday, March 14, 2016. 6:00 PM
- Please RSVP to JMasucci@its.jnj.com by Thursday March 10.
- Time: Social Hour: 6:00 PM.
Talk: 7:00 PM.
- Place: Department of Chemistry, Villanova University (Mendel Hall 154)
Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) is a useful strategy for the study of cell signaling, and primary neurons are an important model for the study of signaling in the nervous system. I will discuss the utility of SILAC in primary neurons to study nerve growth factor signaling despite incomplete labeling of proteins in these non-dividing cells. I will also discuss combining SILAC with Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT) to study brain-derived neurotrophic factor (BDNF)-stimulated synthesis of new proteins.
Dr. Neubert received his B.S. in Biology from Georgetown University and his Ph.D. in Immunology and Infectious Disease from Johns Hopkins University. He then did postdoctoral work in the labs of Dr. James B. Hurley at the University of Washington and Lubert Stryer at Stanford University. After three years as Senior Biochemist at Fournier Pharma GmBH in Heidelberg, in 1998 Dr. Neubert joined the Skirball Institute at the New York University School of Medicine, where he is now Associate Professor of Biochemistry and Molecular Pharmacology and Director of the NYU Protein Mass Spectrometry Core for Neuroscience. His research focuses on development of new methods for protein analysis by mass spectrometry and the study of cell signaling and posttranslational modification of proteins, mostly in neurons.
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