October 2017 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Perspectives on the History of Time-of-Flight Mass Spectrometry
- Speaker:Jane Gale, ASMS archivist
- Date: Monday, October 9, 2017. 6:00 PM
- Please RSVP to XQiu2@ITS.JNJ.com by Thursday October 5.
- Time: Social Hour: 6:00 PM.
Talk: 7:00 PM.
- Place: Department of Chemistry, Villanova University (Mendel Hall 154)
Parking for the monthly meetings of the DVMSDG will change on a monthly basis due to heavy construction on campus over the next 1-2 years. Please check monthly for parking updates. Access to the Mendel Lot (S-3) from the Main Campus Gate on Ithan Avenue is closed due to SEPTA construction. October, January, and March meetings will be during fall/winter/spring breaks and traffic on campus should be greatly reduced. Evening classes will be going on during the other months and parking in Mendel may be limited.
1. To access the Mendel Lot off of Spring Mill Road, ring the doorbell at the gate entrance and ask to raise the gate. All attempts will be made to have the gate raised in advance of the 3 meetings during campus breaks.
2. If you enter through the guard shack on Ithan Avenue, ask the guard for a parking pass for the inner campus M-2 parking garage. The main parking garage (I-1) is across Lancaster Avenue and they may direct you to park there.
Abstract: During the first half-century of the existence of mass spectrometry, the field was dominated by physicists who used magnetic sector mass analyzers to study problems basic to physics. The application of these instruments to chemical and biological problems didn't begin to emerge until just prior to WWII. The instruments that would later come to dominate the study of large molecules - the quadrupole mass filter and Time-of-Flight (TOF) mass analyzer - didn't make their debut until 1953. Early work, even by chemists, was limited to atoms and small molecules, since techniques were not yet available for generating ions from relatively nonvolatile samples without (often uncontrolled) modification of the chemical structure. The application of secondary ion mass spectrometry (SIMS) to organic substrates in the late 1970's and early 1980's, together with the nearly simultaneous development of electrospray ionization (ESI) by Fenn and coworkers and matrix-assisted laser desorption ionization (MALDI) by Karas and Hillenkamp in the late 1980's, removed the volatility barrier to mass spectrometry for very large molecules and paved the way for mass analysis to become a tool essential for the research of chemists, biochemists, and biologists alike.
The field of Time-of-Flight Mass Spectrometry (TOFMS) has grown rapidly from its mid-20th century beginnings. Its history is really three stories combined: one of hardware developments that improved resolution and overcame fundamental limitations of the then current designs, one of advances in electronics that brought into being the possibility of high speed data acquisition over a virtually limitless mass range, and one of innovative sample introduction techniques that enabled the fast, high resolution/high mass capabilities of TOF to be incorporated into new and unanticipated areas of study. It will be my pleasure in this talk to highlight some of the historical developments in time-of-flight mass spectrometry.
Dr. Gale is currently the Archivist and Historian for the American Society for Mass Spectrometry (ASMS). She is also a Principal at Gale-Bentz Consulting, where she is a writer, editor, and education/employment coach. She spent the bulk of her career at Bristol-Myers Squibb overseeing bioanalytical analysis, developing data management solutions, and streamlining and improving processes that impact drug development.
Dr. Gale holds an AB in English Literature, a PhD in Physical Chemistry, and a Black Belt in Six Sigma. A 43-year member of ASMS, she served as Treasurer on two separate occasions. She was also Chair of the North Jersey Mass Spec Discussion Group.
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