January 2018 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Bioanalytical techniques to study compartmentalized metabolism.
- Speaker:Nathaniel Snyder, Drexel University
- Date: Monday, January 8, 2018. 6:00 PM
- Please RSVP to XQiu2@ITS.JNJ.com by Thursday January 4.
- Time: Social Hour: 6:00 PM.
Talk: 7:00 PM.
- Place: Department of Chemistry, Villanova University (Mendel Hall 154)
Parking for the monthly meetings of the DVMSDG will change on a monthly basis due to heavy construction on campus over the next 1-2 years. Please check monthly for parking updates. Access to the Mendel Lot (S-3) from the Main Campus Gate on Ithan Avenue is closed due to SEPTA construction. October, January, and March meetings will be during fall/winter/spring breaks and traffic on campus should be greatly reduced. Evening classes will be going on during the other months and parking in Mendel may be limited.
1. To access the Mendel Lot off of Spring Mill Road, ring the doorbell at the gate entrance and ask to raise the gate. All attempts will be made to have the gate raised in advance of the 3 meetings during campus breaks.
2. If you enter through the guard shack on Ithan Avenue, ask the guard for a parking pass for the inner campus M-2 parking garage. The main parking garage (I-1) is across Lancaster Avenue and they may direct you to park there.
Compartmentalization of metabolism is conserved from cell biology to mammalian physiology. This complicates research where a compartment specific process is critical to the biological question being asked. In the case of gestation, the compartmentalized fetal metabolism remains a major challenge to quantitatively study. At a more fundamental level within the cell, quantifying metabolism within the mitochondria and other sub-cellular compartments remains a challenge. To address these challenges, we have expanded studies in meconium, the first stool of a newborn, examining fetal metabolism across a window of gestation where meconium accumulates. To better quantify sub-cellular metabolism, we have adapted sub-cellular fractionation techniques and stable isotope labeling to quantify mitochondrial vs cytosolic metabolic processes in acyl-coenzyme A metabolism. Combining these methodological approaches with high resolution mass spectrometry, we can perform metabolomics and stable isotope resolved metabolic tracing, allowing both targeted and high dimensional data rich untargeted studies simultaneously.
Nathaniel Snyder is an Assistant Professor at the A.J. Drexel Autism Institute. His current work focuses on identifying and measuring modifiable risk factors for autism spectrum disorder (ASD). The long term goals of this work are to bridge population and individual level scientific approaches and develop a public health approach to prevention of ASD. Current research projects include studies of environmental exposures, metabolic pathways involved in neurodevelopment, and molecular mechanisms that may mediate ASD. Other themes of research within the laboratory include carbon metabolism, cancer metabolism, immune cell metabolism, and drug metabolism. Additional projects include fundamental work on improving sample collection and analysis, as well as refining epidemiological trial design using laboratory measurements.
Nathaniel studied Biochemistry at the University of Maryland and trained at the National Institutes of Health. Dr. Snyder's Ph.D. thesis in Pharmacology at the University of Pennsylvania, under Dr. Ian Blair, concerned analytical measurements of low abundance biological molecules using liquid chromatography-mass spectrometry. Also completed at the University of Pennsylvania, Dr. Snyder's MPH work investigated non-invasive biomarkers of asbestos exposure. Nathaniel has published and presented academic works on analytical chemistry, metabolism, inflammation, and environmental exposure assessment.
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