Delaware Valley Mass Spectrometry Discussion Group
October 1998 Meeting Announcement
Joint Meeting with the Society for Applied Spectroscopy, Delaware Valley Section
- Topic: "LC/MS in the Modern Forensic Explosives Laboratory"
- Speaker: Jeffrey N. Leibowitz, Instrument Manager, Chemistry Unit FBI Laboratory, Washington, DC.
- Date: Thursday, October 8, 1998
- Time: 7:00 p.m. Reception (FREE hors d'oeuvres.. FREE Yes, free. Please come and enjoy a selection of hors d'oeuvres courtesy of the Delaware Valley Section of the Society for Applied Spectroscopy. The hors d'oeuvres will include chicken teriyaki, fried zucchini, franks in jackets, cheese puffs, and assorted vegetables with onion dip. A non-alcoholic fruit punch will be provided.)
7:45 p.m. Talk begins
- RSVP. If you plan to attend this meeting, please contact Sheree Gold by Noon on Monday, October 5, 1998 at 1-302-738-4849. Even though there is no cost to attend the reception or talk, please call so that we can provide sufficient food and seating. Please indicate when you call if you are planning to attend just the talk.
- Place: Holiday Inn Philadelphia International Airport, 45 Industrial Highway, Essington, PA 19029, Telephone: 610-521-2400
- Abstract: In the past, confirmation of explosives residues has been performed by GC/MS in many forensic explosives laboratories. However, most of the explosives of interest are thermally unstable, leaving only breakdown products with retention times for confirmation when using GC/MS. LC/MS offers several advantages over GC/MS for explosives analysis and
confirmation: lower temperatures, molecular ion detection, and higher sensitivity.
Over the last several years, LC/MS has become a vital part of explosives analysis at the FBI Laboratory. In early 1996, a method was developed using electrospray ionization with an API source coupled to a triple-stage quadrupole mass spectrometer. Customizing the mobile phase to promote the formation of analyte-adduct ion pairing resulted in a sensitive and
analyte-specific method for the analysis and confirmation of explosives and explosives residues.
Following the development and validation of the LC/MS electrospray method, the technique was used to confirm the results in several high profile bombing cases. The LC/MS method was then used for the analysis and confirmation in the FBI's unprecedented investigation of the TWA Flight 800 explosion. LC/MS was a vital tool in this investigation with the technique used to analyze over 2,000 samples.
- Bio:Mr. Leibowitz has worked in the Chemistry Unit of the FBI Laboratory for three years, where he has performed examinations and developed methods in the areas of explosives, drugs, dyes, and poisons. Prior to joining the FBI, Mr. Leibowitz was with the Bureau of Alcohol, Tobacco and Firearms, where he worked in the investigation of product contamination
adulteration and tampering. Mr. Leibowitz holds B.S. and M.S. degrees in Chemistry.
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Contact Bill Herron (302) 695-4654 WILLIAM.J.HERRON@usa.dupont.com
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