November 1999 Meeting Announcement, Delaware Valley Mass Spectrometry Discussion Group
- Topic: "Quantitative Analysis by MALDI TOFMS: Fact or Fantasy?"
- Speaker: Kevin Owens, Drexel University
- Date: Monday, November 8, 1999. 7:00 PM
- Time: Social Hour: 7:00 PM.
Talk: 7:30 PM.
- Place: Merck, West Point, 37 Auditorium
MALDI is fast becoming the technique of choice for the qualitative analysis of
both biological and synthetic polymeric systems. Unfortunately, MALDI is
viewed by many workers as being a "pseudo-quantitative" technique. Work in our
laboratory has demonstrated that the lack of quantitative ability can be
directly traced to the sample preparation step. This talk will focus on the
problems of successful sample preparation, and how they may be overcome using
an electrospray deposition process. Data are presented demonstrating the use
of MALDI for quantitative analysis using a series of peptides, proteins and
synthetic polymer samples as examples. Important aspects of the details of the
MALDI sample preparation process, including the key effect of solubility, are
- Bio: Kevin Owens received his bachelor of science degree in chemistry from the
University of New Hampshire in 1982 working with C.L. Grant on the proper use
statistical analysis in analytical chemistry. He then moved to Indiana
University in Bloomington, Indiana and worked with Jim Reilly on supersonic
jet spectroscopy and the analytical applications of laser ionization
time-of-flight mass spectrometry. He joined the faculty of Drexel University
in Philadelphia as an instructor in 1987. He is now an associate professor of
chemistry at Drexel where his research group focuses on exploring the
mechanism of the MALDI process and extending the application of MALDI for
Please send any comments, corrections, or suggestions to
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