Lecture Outline

1. Topic:
   1. What is spectroscopy used for? Some example case studies from Chemir/Polytech consulting laboratories.
      1. materials identification
      2. manufacturing problems
      3. litigation support
      4. failure analysis
   2. The Fourier Transform (lectureintroft.mcd)

2. Reading Assigned For Next Week: (Reading Notes for FTIR Articles)
   1. Fourier Transform-Infrared Spectroscopy, Part I. Instrumentation (Perkins, W.D. J. Chem. Educ.,63, 1986, A5-10.)
   2. Mathcad Basics for Chem 465/467.
   3. Lambert, excerpts from Chapters 7, 8 and 9.
   4. The Stable World of FT-IR (Anal. Chem. 70, 1998, 273A-276A)
   5. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week: (20 pts) introfouriertransform.mcd.

1. Topic:
   1. The Interferometer and FT-IR
   2. FTIR Instrumentation

2. Reading Assigned For Next Week: (Reading Notes for Mass Spectrometry Articles)
   1. An Introduction to Mass Spectrometry
   2. Lambert, Chapter 14 & 15

3. Homework For Next Week:
   1. (20 pts) Infrared group frequencies assignment

1. Topic:
   1. Introduction to Mass Spectrometery

2. Reading Assigned For Next Week: (Reading Notes for Mass Spectrometry Articles)
   1. An Introduction to Mass Spectrometry (Interpretation)
   2. Lambert, Chapter 14 & 15
   3. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week:

1. Topic: Mass Spectrometery, Interpretation

2. Reading Assigned For Next Week: (Reading Notes for Mass Spectrometry Articles)
   1. An Introduction to Mass Spectrometry (Introduction and Ionization Techniques)
   2. Lambert, Chapter 13, section 1-3.
   3. Low Energy, Low Temperature Mass Spectra 6-A Synoptic View. (Maccoll, A. Org. Mass Spectrom.,21, 1986, 601-612)
   4. Chemical Ionization Mass Spectrometry. I. General Introduction. (Munson, M.S.B.. J. Am. Chem. Soc.,88, 1966, 2621-2630)

3. Homework For Next Week: (10 points) Self-Test #1 from An Introduction to Mass Spectrometry
4. Homework, Due in 2 weeks: (40 pts) Mass Spectrometery Unknowns. (Pick 4)

1. Topic: Mass Spectrometery, Ionization.

2. Reading Assigned For Next Week: (Reading Notes for Mass Spectrometry Articles)
   1. An Introduction to Mass Spectrometry (Mass Analyzers through Data Systems)
   2. Lambert, Chapter 13, section 4.
   3. Basics of MS-MS (Busch, K.L. Spectroscopy, 13, 1998, 16-18)
   4. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week: (10 points) Self-Test #2 from An Introduction to Mass Spectrometry

1. Topic: Mass Spectrometery, Mass Analyzers

2. Reading Assigned For Next Week: (Reading Notes for NMR Articles)
   1. Lambert, Chpater 2, section 1-7.
   2. Supplemental The Fourier Transform in Chemistry, Part 1. Nuclear Magnetic Resonance: Introduction

3. Homework For Next Week: (20 points) End of Chapter Questions from An Introduction to Mass Spectrometry

1. Topic: NMR, Introduction

2. Reading Assigned For Next Week:
   1. Lambert, Chapter 2, section 8; Chapter 5, section 1.
   2. Basics of NMR by Joseph Hornak
   3. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week: Take Home Exam (100 pts)

1. Topic: NMR, Data Acquisition

2. Reading Assigned For Next Week: (Reading Notes for NMR Articles)
   1. Van Bramer, S.E. Chemical Shifts in NMR, General. In The Encyclopedia of Analytical Chemistry, Myers, R. Ed; Wiley: New York, 2000
   2. Supplmental The Fourier Transform in Chemistry, Part 2. Nuclear Magnetic Resonance: The Single Pulse Experiment

3. Homework For Next Week:
   1. Mathcad exercise: (10 pts) An Introduction to NMR Concepts, pages 1 through 6
   2. NMR meets MUSICIANS Walter Bauer's paper on audio FID's.

1. Topic: NMR, Data Processing

2. Reading Assigned For Next Week: (Reading Notes for NMR Articles)
   1. Lambert, Chapter 3.
   2. Supplmental The Fourier Transform in Chemistry, Part 3. Nuclear Magnetic Resonance: Multiple-Pulse Experiments
   3. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week: (5 pts) Complete the following Mathcad exercise: An Introduction to NMR Concepts, pages 7 through 12

1. Topic: NMR Interpretation

2. Reading Assigned For Next Week:
   1. Work through lecture notes and web page (H and C spectra) for interpreted spectra.

3. Homework For Next Week: (40 pts) NMR Unknowns (Pick 4 different from previous).

1. Topic: NMR, Pulse Experiments.

2. Reading Assigned For Next Week:
   1. Lambert, Chapter 4
   2. First Spectral Unknown Challenge Revisited.
   3. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week: Complete Mathcad exercise: (10 pts) An Introduction to NMR Concepts, pages 13 through 23

1. Topic: NMR, Advanced Topics

2. Reading Assigned For Next Week: (Reading Notes for NMR Articles)
   1. Lambert, Chapter 5, sections 3, 4, 5, 6, 7; Chapter 6. Sections 1, 2, 3,& 4.
   2. Supplemental Reading The Fourier Transform in Chemistry, Part 4. Nuclear Magnetic Resonance: Two-Dimensional Methods
   3. Work through web page for interpreted spectra of experiments discussed.

3. Homework For Next Week: (40 pts) Spectrometery Unknowns (Pick 4 different from previous).

1. Topic: NMR, 2-D Experiments and Interpretation

2. Reading Assigned For Next Week:
   1. Work through web page for interpreted spectra of experiments discussed.
   2. Work through identification of Citronillal web pages
   3. Spectroscopy in the news. E-mail a brief description of an article from the news (biweekly assignment).

3. Homework For Next Week: