Human
Physiology Biology 325
Spring 2008
(302) 726 0977
no calls after 9:30 PM please
Physiology by Berne Levy Koeppen and Stanton approximately 4th edition
Class
schedule Lab schedule
Course
requirements
OVERVIEW
This course in human physiology integrates the function of individual cells, organs, and systems into a cohesive and comprehensive explanation of the function of the human body. In the pasttwo decades rapid advances in molecular biology lead to an exponential increase in our knowledge of the cellular and molecular mechanisms that underlie the functions of organs and their coordination in other words humanphysiology. This course emphasizes the function of organ systems and their impact on the maintenance of homeostasis and body function as well as the cellular and molecular mechanisms underlying them.
The following
syllabus is very tentative and only reflects my good intentions. Reality and you,will dictate the inevitable
timing changes, additions and deletions. Changes will be announced in advanced
in class (and/or will posted in the course web page).It is the policy of the
Science Division policy is to include a statement about academic integrity in
all science courses syllabi. You should be aware that the Science Division
enforces the University's policy on cheating and other forms of academic fraud
as described in the Student Handbook.
Process Objectives
This course was designed to enhance your:
problem solving skills
quantitative thinking
computational dexterity
writing skills
This course is
divided into sixmodules, each module corresponds to
one or two physiological systems . The modules are : 1) cell physiology2)
excitable tissue -muscle and nervous systems 3) the endocrine system and
bioenergetics (whole body metabolism),4) the cardiovascular andthe
respiratory systems,5) kidney function,and
6) the digestive system.
1) Discuss the structure and function of cell membranes including transport mechanisms and their biochemical detail
2) Describe the electrochemical potentials of ions across membranes,explain and calculate resting potentials and ionic equilibra of the different ions
3) Describe the molecular structure of ion channels and cell membrane transporters and their regulation
4) Discuss and
describe in detail cellular communication and its molecular basis
1) Describe the ionic basis for the generation of action potentials, its properties and coding function
2) Discuss in detail synaptic transmission
3) Give a general outline of the overall structureof the nervous system and describe the functionofeach component
4) Describe the function of the somatovisceral, and special senses sensory systems
5) Discuss in detail the structure function and pharmacology of the autonomic nervous system
6) Detail the structure and function of the central nervous system
7) Describe in detail the basic structure of skeletal muscle, the cellular and molecular processes ofcontractions and the mechanism involve in their regulation
8) Gain a basic understanding of biomechanics and muscle metabolism
7)
Differentiate between the mechanism described above for skeletal muscle and
those employed by cardiac and smooth muscle and describe in detail these
mechanisms.
2) Relate the action of the endocrine system to the overall maintenance of homeostasis
3) Discuss in detail the structure and function of endocrine glands and hormones involved in the control of energy balance and thermoregulation
4) Explain the
biochemical reactions summed up as totalmetabolism
and calculate various parameters involved in energy and thermic
balance (e.g. VO2, C, HP)
2) Describe the ionic and molecular basis for the electrical activity of the heart including basic electrocardiography
3) Discuss the structure of the heart in relation to its function as a pump
4) Discuss the electrical, contract ional and functional implications of the cardiac cycle
5) Describe the regulation andcalculate the various parameters of cardiac output
6) Describe and calculate the various parameters of hemodynamicsand their control mechanisms
7) Describe in detail the structure and function of the respiratory system
8) Calculate the various variables of ventilatory functionand discuss their controls
9) Calculate the various variables of the gas laws and relate them to the function of the respiratory system
10) Discuss the controls and mechanismswhich drive respiration and their cellular and biochemical detail
11) Discuss the
mechanisms and controls of gas transport in blood
2) Outline the different assessment tools and calculate the various variables involve in the assessment of renal function
3) Describe in detail the physical, cellular and molecular processes involved in urine formation
4) Discuss the
regulation of body fluid osmolarity and volume,
electrolyte balance, and acid base balance.
2) Relate the general controls of digestive function to the function of the various organs of the GI tract
3) Discuss the biochemical, cellular and molecular processes involved in digestion and absorption
4) Describe the hormones, their action and mechanisms of action, involved in the control of digestive function
5) Describe the
autonomic and enteric innervations of the GI tract and relate their action to
the control of motility and digestive processes of the GI tract